Study points to virus as culprit in kids’ paralyzing illness

WASHINGTON (AP) — Scientists have found the strongest evidence yet that a virus is to blame for a mysterious illness that can start like the sniffles but quickly paralyze children.

The poliolike syndrome, called acute flaccid myelitis or AFM, is very rare. Since the first reports from California in 2012, the U.S. has experienced an increasingly bigger outbreak every other year, from late summer into fall.

Doctors have a chief suspect but proof that it’s the culprit germ has been frustratingly elusive.

So researchers tried a new trick: They checked patients’ spinal fluid for signs the immune system had fought an invading virus. Sure enough, kids who got sick harbored antibodies that target enteroviruses, just the viral family specialists believe is to blame.

“This is circumstantial evidence that this is what’s going on, but it’s a powerful piece of circumstantial evidence,” said Dr. Michael Wilson of the University of California, San Francisco, who helped lead the research. His team reported the findings Monday in Nature Medicine.

Nailing down a suspect is key to better diagnosis and eventually finding a way to prevent or treat the illness, said study co-author Dr. Riley Bove, a neurologist at the university whose own son developed AFM at age 4.

“If you don’t have a cause, you can’t have a vaccine,” Bove noted. Wilson developed “a good enough microscope, in a sense, to find things they suspected were there.”

Some 590 cases of the ailment have been confirmed in the U.S. since the Centers for Disease Control and Prevention began counting in 2014. Cases spiked that year and in 2016 and last year, with just a few in the intervening years. So far, there have been 22 this year.

Bove’s son, Luca Waugh, illustrates the pattern: His whole family caught a cold in the summer of 2014 — and a few days later, Luca woke up with weakness in his neck that traveled down his shoulder. Despite fast hospitalization, within days he had body-wide paralysis and trouble breathing. He recovered gradually, and today still has some paralysis in his neck, shoulder and arm.

Either a germ or the body’s reaction to a germ was damaging nerves in the spinal cords of patients like Luca. The CDC noted that AFM spikes coincided with seasons when certain strains of enteroviruses — named EV-D68 and EV-A71 — were causing widespread respiratory illnesses. The problem: Doctors seldom found those viruses in the patients’ spinal fluid, leaving doubt about the link.


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