SEATTLE (AP) — John Means threw the major leagues’ third no-hitter this season and came within a wild pitch on a third strike of a perfect game, pitching the Baltimore Orioles over the Seattle Mariners 6-0 on Wednesday.

Means (4-0) struck out 12. Seattle’s Sam Haggerty raced to first after he struck out swinging on a curveball in the dirt on a 1-2 count with one outs in the third inning that bounced away from catcher Pedro Severino.

Haggerty wasn’t on base long, getting thrown out attempting to steal second.

Means threw 79 strikes among 113 pitches, including first-pitch strikes to 26 of 27 batters. When Seattle did make contact against the 28-year-old left-hander, it was weak and there were no threats to fall in for a hit.

Means lowered his ERA to 1.37 and became the first individual Orioles pitcher to toss a no-hitter since Jim Palmer against Oakland on Aug,. 13, 1969. It was the 10th no-hitter in franchise history — six in Baltimore after four as the St. Louis Browns.

Means joined a no-hit club that includes gems by San Diego right-hander Joe Musgrove at Texas on April 9 and by Chicago White Sox left-hander Carlos Rodón against Cleveland on April 14. In addition, Arizona left-hander Madison Bumgarner pitched a seven-inning no-hitter against Atlanta on April 25, but that is not recognized as an official no-hitter because the game did not go at least nine innings, shortened under pandemic rules in effect for a second straight season.

Baltimore’s previous no-hitter came on July 13, 1991, when Bob Milacki, Mike Flanagan, Mark Williamson and Gregg Olson combined for a 2-0 victory at Oakland.

Means had plenty of offensive support. D.J. Stewart and Ramón Urias both had RBI singles against Yusei Kikuchi in the third inning. Pat Valaika hit a solo home run off Kikuchi (1-2) in the sixth and Trey Mancini provided a three-run shot off reliever Aaron Fletcher in the eighth inning.

Yankees 6, Astros 3

NEW YORK (AP) — Giancarlo Stanton homered again and knocked in four runs, Aaron Hicks hit a tiebreaking single in the eighth inning and New York beat Houston for its fifth straight victory.

With fans in the Bronx chanting curses at José Altuve and several other Astros for the second consecutive night, the Yankees (16-14) got three innings of scoreless relief from their major league-best bullpen and won for the 10th time in 13 games to move two games above .500 for the first time this season.

New York will try for a three-game sweep Thursday afternoon, with ace Gerrit Cole facing Houston for the first time since leaving the Astros for a $324 million, nine-year contract with the Yankees before the 2020 season.

Jonathan Loaisiga (3-1) pitched a hitless eighth and Aroldis Chapman struck out two in a perfect ninth for his seventh save. Brooks Raley (0-2) was the loser.

Cardinals 4, Mets 1,

1st game

ST. LOUIS (AP) — Paul DeJong hit a two-run homer, Paul Goldschmidt added a solo shot off Marcus Stroman and St. Louis beat New York in a doubleheader opener for its sixth straight victory.

Kwang Hyun Kim pitched four innings, combining with Ryan Hemsley (3-0), Giovanny Gallegos and Alex Reyes (ninth save in nine chances) on a two-hitter.

While the Mets received uplifting news earlier in the day when manager Luis Rojas said ace Jacob deGrom could return to the rotation on Sunday, skidding New York did little at the plate in its first game after hitting coach Chili Davis was fired and replaced by Hugh Quattlebaum.

Stroman dropped to 3-3.

Braves 5, Nationals 3

WASHINGTON (AP) — Marcell Ozuna hit Atlanta’s third grand slam in four games, Max Fried pitched five strong innings in his return from the injured list and the Braves beat Washington.

Fried (1-1) allowed one run and four hits, struck out six and walked one, lowering his ERA from 11.45 to 8.44. He had been sidelined since April 14 with a strained right hamstring.

Rookie William Contreras hit his first career homer for the Braves in his third start, replacing the injured Travis d’Arnaud at catcher.

Washington’s Trea Turner hit his team-leading seventh homer, a two-run drive in the eighth inning off Josh Tomlin. A.J. Minter loaded the bases with two outs but got Victor Robles to pop out, and Will Smith worked the ninth for his sixth save in six opportunities.

Erick Fedde (2-3) was the loser.

Rockies 6, Giants 5

DENVER (AP) — Jon Gray tossed six strong innings and helped himself with an RBI single in Colorado’s victory over San Francisco.

Gray (4-2) allowed two runs and four hits. The right-hander struck out eight and walked two while improving to 4-0 in five home starts. Daniel Bard worked a shaky ninth for his third save.

Brandon Crawford continued his hot hitting against the Rockies with a two-run homer in the second inning. Crawford is 10 for 23 with four homers, six walks and 10 RBIs in eight games against Colorado this season.

Giants starter Logan Webb (1-3) was the loser.

Darin Ruf hit a two-run homer for San Francisco.

Phillies 5, Brewers 4

PHILADELPHIA (AP) — Didi Gregorius hit his eighth career grand slam and Philadelphia beat Milwaukee for its third straight victory.

The Phillies won three straight games for the first time since opening 4-0.

Enyel De Los Santos left two runners stranded to end the eighth. José Alvarado returned from a two-game suspension for triggering a bench-clearing incident and worked a scoreless ninth for his second save.

Brandon Kintzler (2-1) tossed 1 1/3 scoreless innings for the win.

Gregorius’ slam off Freddy Peralta (3-1) highlighted a five-run first inning, and six pitchers preserved the win. Gregorius has three grand slams in 86 career games with the Phillies.

Marlins 8, Diamondbacks 0

MIAMI (AP) — Adam Duvall hit his fifth home run and finished with four RBIs, Miguel Rojas scored three times and five Miami pitchers scattered five hits to lead the Marlins over Arizona.

Duvall connected for a three-run homer in a four-run second off Luke Weaver (1-3), Duvall’s first home run in 19 games.

Rojas was 2 for 3 and drove in two runs for Miami, which remained under .500 at 13-16 but is the only team in the NL East to have outscored opponents. Of the Marlins’ plus-18 differential, 14 was in the two games of this series, which began with 9-3 victory.

Jordan Holloway (1-0), the second Marlins pitcher in a bullpen game, allowed two hits and struck out three in three innings.